randomized double

randomized double

A MultipleDose, Randomized, DoubleBlind, Placebo

Delta9tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray has proved efficacious in the treatment of spasticity in multiple sclerosis and chronic pain. A thorough QT/QTc study was performed to investigate the effects of THC/CBD spray on electrocardiogram (ECG) parameters in compliance with regulatory requirements, evaluating the effect of a recommended daily dose (8 sprays/day

A MultipleDose, Randomized, DoubleBlind, Placebo

Delta9tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray has proved efficacious in the treatment of spasticity in multiple sclerosis and chronic pain. A thorough QT/QTc study was performed to investigate the effects of THC/CBD spray on electrocardiogram (ECG) parameters in compliance with regulatory requirements, evaluating the effect of a recommended daily dose (8 sprays/day A Multicenter, Randomized, Double-blind, Placebo This multicenter, randomized, double-blind and placebo-controlled study demonstrates that the strain S. boulardii CNCM I-3799 is effective in the management of acute diarrhea in children. S. boulardii , administered as an adjunctive standard treatment of ORS and zinc supplementation, was associated with beneficial effects on several clinical features of diarrhea.

A Multicenter, Randomized, Double-blind, Placebo

This randomized, double-blind, placebo-controlled trial was designed to evaluate the efficacy and safety of Saccharomyces cerevisiae var. boulardii CNCM I-3799 in the management of acute diarrhea in children. Ethics and Regulatory Approval A Randomized Double-Masked Phase 2a Trial to Evaluate Jan 18, 2021 · A Randomized Double-Masked Phase 2a Trial to Evaluate Activity and Safety of Topical Ocular Reproxalap, a Novel RASP Inhibitor, in Dry Eye Disease. Jan 18, 2021 To determine whether reproxalap, a novel reactive aldehyde species (RASP) inhibitor, is safe and effective for the treatment of the signs and symptoms of dry eye disease (DED).

A Randomized Trial of Hydroxychloroquine as Postexposure

In this randomized, double-blind, placebo-controlled trial, we investigated the efficacy of hydroxychloroquine as Covid-19 postexposure prophylaxis. In this trial, high doses of A Randomized, Double-Blind Comparison of Lactated olution (LR). We hypothesized that NS is detrimental to renal function in kidney transplant recipients. Adults undergoing kidney transplantation were enrolled in a prospective, randomized, double-blind clinical trial of NS versus LR for intraoperative IV fluid therapy. The primary outcome measure was creatinine concentration on postoperative Day 3. The study was terminated for safety reasons

A Randomized, Double-Blind, Controlled Trial Comparing

In this prospective double-blind randomized controlled trial, 120 patients with overt HE were randomized into two groups:(group A lactulose plus rifaximin 1,200 mg/day;n=63) and group B (lactulose (n=57) plus placebo). The primary end point was complete reversal of HE and the secondary end points were mortality and hospital stay. A Randomized, Double-blind, Placebo-controlled Study of Dec 07, 2018 · A Randomized, Double-blind, Placebo-controlled Study of SRP-9001 for Duchenne Muscular Dystrophy (DMD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it

A pilot, randomized, doubleblind, placebocontrolled

A doubleblind, placebocontrolled human trial was conducted to evaluate the safety and efficacy of a standardized oral supplementation of Boswellin®, a novel extract of Boswellia serrata extract (BSE) containing 3acetyl11ketoboswellic acid (AKBBA) with boswellic acid (BBA). A total of 48 patients with osteoarthritis (OA) of the knee were randomized and allocated to A prospective, randomized, double-blind study of Questions have been raised regarding the safety of trimethoprim-sulfamethoxazole (TMP-SMZ) in organ transplantation, particularly adverse interactions with azathioprine and cyclosporine. In a prospective randomized, double-blind, trial in 132 patients that encompassed 33,876 patient-days, long-term

A randomized, double-blind, placebo-controlled study of

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain Pain. 2020 Apr 24;10.1097/j.pain.0000000000001896. doi:10.1097/j.pain.0000000000001896. Online ahead of print. Authors Chris D Verrico 1 A randomized, double-blind, placebo-controlled study of A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain. Verrico, Chris D. a,b; properties and significantly improved the mobility of large domestic canines afflicted with osteoarthritis in a double-blinded, placebo-controlled veterinary study.

A randomized, double-blind, placebo-controlled study of

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain. Verrico, Chris D. a,b; properties and significantly improved the mobility of large domestic canines afflicted with osteoarthritis in a double-blinded, placebo-controlled veterinary study. A randomized, double-blind, placebo-controlled study of A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain. Verrico, Chris D. a,b; properties and significantly improved the mobility of large domestic canines afflicted with osteoarthritis in a double-blinded, placebo-controlled veterinary study.

Colchicine Coronavirus SARS-CoV2 Trial (COLCORONA) -

Mar 26, 2020 · This is a phase 3, randomized, double-blind, placebo-controlled multicenter study to evaluate the efficacy and safety of colchicine in adult patients diagnosed with COVID-19 infection and have at least one high-risk criterion. Approximately 6000 subjects meeting all inclusion and no exclusion criteria will be randomized to receive either Double-Blind, Randomized, Placebo-Controlled Phase III Oct 15, 2020 · This is a Phase III, randomized, multicenter, endpoint driven, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of the adsorbed vaccine COVID-19 (inactivated) produced by Sinovac. The adsorbed vaccine COVID-19 (inactivated) produced by Sinovac (product under investigation) will be compared to placebo.

Double-Blind, Randomized, Placebo-Controlled Phase III

Oct 15, 2020 · This is a Phase III, randomized, multicenter, endpoint driven, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of the adsorbed vaccine COVID-19 (inactivated) produced by Sinovac. The adsorbed vaccine COVID-19 (inactivated) produced by Sinovac (product under investigation) will be compared to placebo. Efficacy and Safety of Upadacitinib in a Randomized Methods:In this double-blind, placebo (PBO)-controlled, phase 2/3 study (NCT03178487; SELECT-AXIS 1) pts with AS were randomized 1:1 to UPA 15 mg or matching placebo. Enrolled pts (18 y) met modified New York Criteria for AS based on central reading of radiographs, had a BASDAI 4 and pt assessment of total back pain 4 (numeric rating

Immunogenicity and safety of fractional doses of yellow

Jan 11, 2021 · Researchers designed a randomized, double-blind, non-inferiority trial at research centers in Mbarara, Uganda, and Kilifi, Kenya. They evaluated 1,029 participants for inclusion between November 6, 2017, and February 21, 2018, with 960 participants ultimately enrolled and randomized to vaccine manufacturer and dose. Immunogenicity and safety of fractional doses of yellow Jan 11, 2021 · Researchers designed a randomized, double-blind, non-inferiority trial at research centers in Mbarara, Uganda, and Kilifi, Kenya. They evaluated 1,029 participants for inclusion between November 6, 2017, and February 21, 2018, with 960 participants ultimately enrolled and randomized to vaccine manufacturer and dose.

Lactobacillus reuteri DSM 17938 in Infantile Colic:A

OBJECTIVE:To test the efficacy of Lactobacillus reuteri on infantile colic and to evaluate its relationship to the gut microbiota. STUDY DESIGN:Fifty exclusively breastfed colicky infants, diagnosed according to modified Wessel's criteria, were randomly assigned to receive either L reuteri DSM 17 938 (108 colony-forming units) or placebo daily for 21 days. NAVIGATOR:a phase 3 multicentre, randomized, double Oct 13, 2020 · Study design. NAVIGATOR is an ongoing phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group study that aims to evaluate the effect of tezepelumab 210 mg Q4W administered subcutaneously in adults (1880 years old) and adolescents (1217 years old) with severe, uncontrolled asthma.

Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus

PURPOSE Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the efficacy and safety of GC4419, a superoxide dismutase mimetic, with placebo to reduce the duration, incidence, and severity of severe OM (SOM). PATIENTS AND METHODS A total of Preoperative intravenous iron to treat anaemia before In a double-blind, parallel-group randomised trial, we recruited adult participants identified with anaemia at preoperative hospital visits before elective major open abdominal surgery at 46 UK tertiary care centres. Anaemia was defined as haemoglobin less than 130 g/L for men and 120 g/L for women.

Prospective, randomized, doubleblind assessment of

Jun 27, 2018 · This was a randomized, doubleblind, 12week study in which 44 patients were asked to apply either bakuchiol 0·5% cream twice daily or retinol 0·5% cream daily. A facial photograph and analytical system was used to obtain and analyse highresolution photographs of Randomised trials Cancer Research UKRandomised trials have at least 2 different treatment groups. The people taking part are put into one of the groups at random. This process is called 'randomisation' and is usually done by a computer. Most phase 3 trials and some phase 2 trials are randomised.

Randomized controlled trials:Overview, benefits, and

Dec 04, 2018 · A randomized controlled trial is one of the best ways of keeping the bias of the researchers out of the data and making sure that a study gives the fairest representation of a Randomized, Double-Blind, Placebo-Controlled, Multicenter Jan 20, 2017 · 1. J Clin Oncol. 2017 Jan 20;35(3):343-351. doi:10.1200/JCO.2015.64.7685. Epub 2016 Dec 5. Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study of Onartuzumab Plus Bevacizumab Versus Placebo Plus Bevacizumab in Patients With Recurrent Glioblastoma:Efficacy, Safety, and Hepatocyte Growth Factor and O6-Methylguanine-DNA Methyltransferase Biomarker

Randomized, double-blinded and placebo-controlled phase

Methods:In this randomized, double-blinded and controlled trial, healthy adults received a medium (MD) or a high dose (HD) of the vaccine at an interval of either 14 days or 28 days. Neutralizing antibody (NAb) and anti-S and anti-N antibodies were detected at different times, and adverse reactions were monitored for 28 days after full immunization. Remdesivir in adults with severe COVID-19:a randomised We did a randomised, double-blind, placebo-controlled, multicentre trial at ten hospitals in Hubei, China. Eligible patients were adults (aged 18 years) admitted to hospital with laboratory-confirmed SARS-CoV-2 infection, with an interval from symptom onset to enrolment of 12 days or less, oxygen saturation of 94% or less on room air or a ratio of arterial oxygen partial pressure to

SOURCE:a phase 3, multicentre, randomized, double-blind

Oct 13, 2020 · SOURCE is an ongoing phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group study that aims to evaluate the effect of tezepelumab 210 mg administered subcutaneously every 4 weeks (Q4W) on OCS dose reduction in adults with OCS-dependent asthma. Patient recruitment for SOURCE has been completed. Safety and immunogenicity of an inactivated SARS-CoV-2 We did a randomised, double-blind, placebo-controlled, phase 1/2 trial at Shangqiu City Liangyuan District Center for Disease Control and Prevention in Henan Province, China. In phase 1, healthy people aged 1880 years, who were negative for serum-specific IgM/IgG antibodies against SARS-CoV-2 at the time of screening, were separated into two

Three Multicenter, Randomized, DoubleBlind, Placebo

Sep 18, 2018 · Three Multicenter, Randomized, DoubleBlind, PlaceboControlled Studies Evaluating the Efficacy and Safety of Ustekinumab in Axial Spondyloarthritis. Atul Deodhar MD. Corresponding Author. E-mail address:[email protected] Oregon Health & Science University, Portland. Tocilizumab in systemic sclerosis:a randomised, double Methods:In this multicentre, randomised, double-blind, placebo-controlled, phase 3 trial, participants were recruited from 75 sites in 20 countries across Europe, North America, Latin America, and Japan. Adults with diffuse cutaneous systemic sclerosis for 60 months or less and a modified Rodnan skin score (mRSS) of 10-35 at screening were

Use of proton pump inhibitors to treat persistent throat

Jan 07, 2021 · Objective To assess the use of proton pump inhibitors (PPIs) to treat persistent throat symptoms. Design Pragmatic, double blind, placebo controlled, randomised trial. Setting Eight ear, nose, and throat outpatient clinics, United Kingdom. Participants 346 patients aged 18 years or older with persistent throat symptoms who were randomised according to recruiting centre and baseline What Is a Double-Blind Study? - Verywell MindIn one research article, randomized double-blind placebo studies were identified as the "gold standard" when it comes to intervention-based studies. One of the reasons for this is the fact that random assignment reduces the influence of confounding variables.

A Randomized Double-Masked Phase 2a Trial to Evaluate

Jan 18, 2021 · A Randomized Double-Masked Phase 2a Trial to Evaluate Activity and Safety of Topical Ocular Reproxalap, a Novel RASP Inhibitor, in Dry Eye Disease. Jan 18, 2021 To determine whether reproxalap, a novel reactive aldehyde species (RASP) inhibitor, is safe and effective for the treatment of the signs and symptoms of dry eye disease (DED).

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